The Importance of Systemic Inflammatory Response Index, Systemic Immune-Inflammation Index, and Hemoglobin-Albumin-Lymphocytes-Platelets (HALP) Score in Children with Cancer

Background: Biological inflammatory status in cancer patients is evaluated with various parameters. Limited studies have been conducted on this issue children. Objectives: This study was done to evaluate the importance of biological status, including systemic response index (SIRI), immune-inflammation (SII) index, and hemoglobin-albumin-lymphocytes-platelets (HALP) score children cancer. Methods: Demographic characteristics, complete blood count, biochemical analysis admission were recorded retrospectively. Since not meeting necessary assumptions, Mann-Whitney U test used for comparison two groups, Kruskal-Wallis more than groups Results: The SIRI statistically higher control group (P < 0.0001). Considering lymphoma, central nervous system tumors, solid there a statistical difference between SII values: .0245, .0060, respectively). Regarding biomarkers, according extent (localized or advanced disease), it found that disease = 0.0175). who died had HALP 0.0472). Conclusions: biomarkers can be childhood cancers determine predict outcomes. However, larger patient series, ideal values should achieved by analyzing receiver operating characteristic curves area under curve.